Relieve swollen, painful, heavy and tired legs.

FOR SOUTH AFRICAN RESIDENTS

Antistax^® is a naturally derived supplement for leg vein health. It comes in easy to take tablets containing an extract of red vine leaf AS 195 (Bio-Active Flaven) which helps provide relief from Chronic Venous Insufficiency (CVI) symptoms, such as: swollen, painful, heavy and tired legs¹

*Dosing from Patient Information Leaflet

ANTISTAX® Active Leg tablets. Reg. no.:48/32.2/1076. Each tablet contains dry extract of red vine leaf AS 195 (4 - 6:1) 360 mg per tablet. For full prescribing information refer to the professional information approved by the South African Health Products Regulatory Authority (SAHPRA).

ANTISTAX® Double Fresh Gel contains Red Vine Leaf Extract. Western herbal. This unregistered medicine has not been evaluated by the SAHPRA for its quality, safety or intended use.

HCR: Imperial Market Access Healthcare SA (Pty) Ltd, 10 Skeen Boulevard, Bedfordview, Gauteng, 2007. Reg. no.: 2006/029994/07.

General contact information: info.mahsa.sm@dpworld.com Tel: 012 621 4300. For any quality or safety related queries, please contact Imperial Quality at Quality.healthcare.sm@dpworld.com or Imperial Medical at pvimperiallogistics@dpworld.com.

References: 1. Antistax PIL 2. Antistax Double Fresh Gel PIL 3. Kiesewetter H. Koscielny J, Kalus U et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II): a randomised, double-blind, placebo-controlled trial. Arzneim.-Forsch./Drug Res 2000;50(1):109-117. 4. Kalus U, Koscielny J, Grigorov A et al. Improvement of cutaneous microcirculation and oxygen supply in patients with Chronic Venous Insufficiency by orally administered extract of red vine leaves AS 195: a randomised, double-blind, placebo-controlled, crossover study. Drugs R&D 2004; 5(2): 63-71. 5. Nees S, Weiss DR, Reichenblach-Klinke E et al. Protective Effects of Flavonoids Contained in the Red Vine Leaf on Venular Endothelium against the Attack of Activated Blood Components in vitro. Arzneim.-Forsch./Drug Res. 2003;53(5):330-341. 6. (last accessed 12 December 2023) 7. Francoise Pitsch. Results of the DECIDE survey: appraisal of the predictive value for chronic venous disease of a symptom. Phlebolymphology Vol 18. No. 3. 2011 8. NCBI - WWW Error Blocked Diagnostic (last accessed 13 December 2023) 9. The Epidemiology of Chronic Venous Insufficiency and Varicose Veins by Jennifer L. Beebe-Dimmer, John R Pfeifer, Jennifer S. Engle and David Schottenfeld. March 2005 SAZA.ANTI.19.08.0315